Associate Professor of the Department
Candidate of Chemical Sciences, Associate Professor
In 2010, he graduated with honours from the Faculty of Physics of the Belarusian State University (speciality Physics, research activity, Department of Biophysics).
In 2010, he entered postgraduate studies at the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus in speciality 02.00.10 – bioorganic chemistry.
In 2015, he defended his dissertation for the degree of Candidate of Chemical Sciences.
From 2010 to the present, he has worked as a Junior Researcher, Researcher, Senior Researcher and Leading Researcher at the Laboratory of Protein Engineering of the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus.
Since 2020 to the present – Associate Professor at the Department of Natural Sciences of the University of the National Academy of Sciences of Belarus (part-time).
Leading Researcher at the Laboratory of Protein Engineering of the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus.
In 2023, he entered doctoral studies at the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus. Dissertation topic: “Modelling of the process of protein-ligand interaction using deep learning technology.”
Awards and prizes:
2014 – Laureate of the TOP-10 results competition of scientists of the National Academy of Sciences of Belarus in the field of fundamental and applied research.
2015, 2020 – Scholarship of the President of the Republic of Belarus for talented young scientists.
2020 – Prize of the National Academy of Sciences of Belarus in the field of chemical sciences and earth sciences.
Author of more than 80 scientific publications, including 30 articles in peer-reviewed scientific journals. Author of a book devoted to the application of computer modelling methods for the search for chemical compounds with desired properties, 7 acts of implementation into the educational process and 2 certificates of registration of computer programs.
Research interests:
- in vitro and in silico study of structural and functional characteristics of human cytochrome P450;
- search for new regulators of enzyme activity in extensive libraries of chemical compounds;
- development and practical application of effective algorithms for virtual screening of ligands of the active site of proteins.
Main publications:
- Computer modelling of molecular structure and reactivity / Y.V. Dichenko; National Academy of Sciences of Belarus, Institute of Bioorganic Chemistry. – Minsk: Belaruskaya Navuka, 2023. – 137 p.
- Design and synthesis of phosphoryl-substituted steroidal pyridazines (Pho-STPYRs) as potent estrogen receptor alpha inhibitors: targeted treatment of hormone-dependent breast cancer cells / Y. Volkova, A. Scherbakov, Y. Dzichenka, A. Komkov, F. Bogdanov, D. Salnikova, A. Dmitrenok, A. Sachanka, D. Sorokin, I. Zavarzin // RSC Med. Chem. – 2024. – Vol. 15. – P. 2380-2399.
- Exploration and biological evaluation of 20-vinyl pregnenes: A step forward toward selective modulators of the estrogen receptor α signaling for breast cancer treatment / V. Malakhova, A. Scherbakov, D. Sorokin, H. Leanavets, Y. Dzichenka, I. Zavarzin, Y. Volkova // Archiv der Pharmazie. – 2024. – V. 357, iss. 7. – e2300651.
- Predictive model for identification of new CYP19A1 ligands on the KNIME analytical platform / M. I. Shaladonova, Y. V. Dichenko, S. A. Usanov // Proceedings of the National Academy of Sciences of Belarus. – 2023. – Vol. 67, No. 5. – P. 431-440.
- Discovery of highly potent proapoptotic antiestrogens in a series of androst-5,16-dienes D-modified with imidazole-annulated pendants / V. Birukova, A. Scherbakov, A. Ilina, D. Salnikova, O. Andreeva, Y. Dzichenka, I. Zavarzin, Y. Volkova // The Journal of Steroid Biochemistry and Molecular Biology. – 2023. – V. 231. – P. 106309. – doi: 10.1016/j.jsbmb.2023.106309.
- Modified bile acids and androstanes – Novel promising inhibitors of human cytochrome P450 17A1 / Y. Dzichenka, M. Shapira, A. Yantsevich, T. Cherkesova, L. Grbović, M. Savić, S. Usanov, S. Jovanović-Šanta // The Journal of Steroid Biochemistry and Molecular Biology. – 2021. – V. 205 – doi.org/10.1016/j.jsbmb.2020.105777.
- Molecular dynamics simulation as a tool for prediction of the properties of TiO2 and TiO2:MoO3 based chemical gas sensors / N. Boboriko, Y. Dzichenka // Journal of Alloys and Compounds. – 2021. – V. 855, No. 2. – doi.org/10.1016/j.jallcom.2020.157490.
- Novel alkylaminoethyl derivatives of androstane 3-oximes as anticancer candidates: synthesis and evaluation of cytotoxic effects / J. J. Ajduković, D. S. Jakimov, L. Rárová, M. Strnad, Y. U. Dzichenka, S. Usanov, D. Đ. Škorić, S. Jovanović-Šanta, M. N. Sakač // RSC Adv. – 2021. – V. 11. – P. 37449-37461.
- In silico analysis of interaction of compounds containing photoactivatable groups with human CYP7 enzymes / Y.V. Dichenko, M.S. Khoretsky, Y.V. Faletrov, A.V. Yantsevich, Corresponding Member V.M. Shkumatov, Corresponding Member S.A. Usanov // Proceedings of the National Academy of Sciences of Belarus. – 2020. – Vol. 64, No. 5. – P. 558-566.
- Fe(III)-Catalyzed synthesis of steroidal imidazoheterocycles as potent antiproliferative agents / S. Samanta, A. K. Ghosh, S. Ghosh, A. A. Ilina, Y. A. Volkova, I. V. Zavarzin, A. M. Scherbakov, D. I. Salnikova, Y. U. Dzichenka, A. B. Sachenko, V. Z. Shirinian, A. Hajra // Organic & Biomolecular Chemistry. – 2020. – V. 18, No. 29. – P. 5571-5576.